Treatment of hypercalcemia associated with sarcoidosis †. Usually ameliorates hypercalcemia associated with bone involvement in multiple myeloma.
Treatment of hypercalcemia associated with malignancy. In hypertensive forms, a “short-acting” glucocorticoid with minimal mineralocorticoid activity (e.g., prednisone) is preferred avoid long-acting glucocorticoids (e.g., dexamethasone) because of tendency toward overdosage and growth retardation. After early childhood, a glucocorticoid alone is used for long-term therapy throughout life. In salt-losing forms, cortisone or hydrocortisone is preferred in conjunction with liberal salt intake an additional mineralocorticoid may be necessary through ≥5–7 years of age. Lifelong glucocorticoid treatment of congenital adrenogenital syndrome (also known as congenital adrenal hyperplasia). In infants, mineralocorticoid supplementation is particularly important.
Adrenocortical InsufficiencyĬorticosteroids are administered in physiologic dosages to replace deficient endogenous hormones in patients with adrenocortical insufficiency.Ĭortisone or hydrocortisone is the corticosteroid of choice for replacement therapy in patients with adrenocortical insufficiency because these drugs have both glucocorticoid and mineralocorticoid properties. Supportive therapy used adjunctively with other indicated therapies. Glucocorticoid therapy is not curative rarely indicated as the primary method of treatment. When used for anti-inflammatory and immunosuppressant properties, synthetic glucocorticoids that have minimal mineralocorticoid activity are preferred. Treatment of a wide variety of diseases and conditions principally used for glucocorticoid effects as an anti-inflammatory and immunosuppressant agent, and for its effects on blood and lymphatic systems in the palliative treatment of various diseases.
Glucocorticoid secreted by the adrenal cortex also exhibits mineralocorticoid activity.
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